分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药

赵丹妮; 吴贝贝; 吐尔洪·买买提

doi:10.13568/j.cnki.651094.651316.2021.10.29.0001

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分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药

化学与化工 | 更新时间：2026-01-21

- 分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药
- 分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药
- 新疆大学学报（自然科学版中英文） 2022年39卷第6期页码：688-695
- 作者机构：
  
  1. 新疆大学化学学院省部共建碳基能源资源化学与利用国家重点实验室
  2. 中国石油化工股份有限公司西北油田分公司工程技术研究院
- 作者简介：
- 基金信息：
  
  国家自然科学基金（21565025;22064015）
- DOI：10.13568/j.cnki.651094.651316.2021.10.29.0001
  中图分类号： O657.72;TQ658
- 纸质出版：2022
- 稿件说明：
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[1]赵丹妮,吴贝贝,吐尔洪·买买提.分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药[J].新疆大学学报(自然科学版)(中英文),2022,39(06):688-695.
[1]赵丹妮,吴贝贝,吐尔洪·买买提.分子印迹聚合物吸头整体柱固相萃取结合GC-MS测定化妆水中的局麻药[J].新疆大学学报(自然科学版)(中英文),2022,39(06):688-695. DOI： 10.13568/j.cnki.651094.651316.2021.10.29.0001.

DOI：10.13568/j.cnki.651094.651316.2021.10.29.0001.

摘要

利用分子印迹吸头整体柱结合便捷、高效固相萃取装置与萃取方法对化妆水中5种局麻药进行探究，并采用GC-MS实现了准确、灵敏的测定．以布比卡因分子印迹聚合物(MIPs)为选择性吸附剂，超高分子量聚乙烯为粘结剂，在移液吸头中通过共烧结制备了分子印迹吸头整体柱固相萃取(PT-SPE)装置．当pH=9.00、10%乙腈水为上样溶剂、甲醇为洗脱溶剂时，PT-SPE对化妆水中局麻药的萃取率最高，且处理后样品基质干扰显著降低，谱图变“干净”，5种局麻药LOQs为0.06～0.09 mg·L-1，该样品前处理方法简化了对化妆水样品的萃取步骤，有效地提高了对化妆水样品测定的灵敏度，实现了对5种局麻药的准确测定．

Abstract

In this paper

a convenient and efficient pipette tip solid-phase extraction(PT-SPE) device and corresponding method were developed and coupling it with GC-MS enabled accurate and sensitive determination of local anesthetics in toner. PT-SPE device was fabricated by co-sintering of bupivacaine molecularly imprinted polymers(MIPs) as selective adsorbent and ultra-high molecular weight polyethylene as co-sintering agent. The optimal extraction conditions for local anesthetics in toner sample by PT-SPE were pH=9.00

10% acetonitrile water as the loading solvent and methanol as the elution solvent. Under these conditions

a clean chromatogram of the sample was obtained

proving that the treated sample contains less matrix interference and the LOQs of local anesthetics were 0.06～0.09 mg·L-1. The sample pretreatment method simplified the extraction steps

effectively improved the sensitivity of the determination of the toner sample

and enabled the accurate determination of five local anesthetics.

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