共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面

金楠; 陈欣; 黄李琼

doi:10.13568/j.cnki.651094.651316.2023.05.14.0002

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共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面

生命科学与技术 | 更新时间：2026-01-21

- 共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面
- 共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面
- 新疆大学学报（自然科学版中英文） 2023年40卷第6期页码：733-740
- 作者机构：
  
  1. 莆田学院药学与医学技术学院药学系
  2. 莆田学院药物分析与检验医学福建省高校重点实验室
- 作者简介：
- 基金信息：
  
  福建省自然科学基金“应用多重响应的姜黄素透皮制剂联合蓝光治疗银屑病的研究”（2020J05205）;福建省省级大学生创新创业训练计划项目“姜黄素智能响应型烫伤敷料的制备及应用”（s202111498020）;莆田市科技局莆田学院科研创新专项“抗衰老活性物质筛选平台”（2021ZP01）
- DOI：10.13568/j.cnki.651094.651316.2023.05.14.0002
  中图分类号： R285.5
- 纸质出版：2023
- 稿件说明：
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[1]金楠,陈欣,黄李琼.共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面[J].新疆大学学报(自然科学版)(中英文),2023,40(06):733-740.
[1]金楠,陈欣,黄李琼.共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面[J].新疆大学学报(自然科学版)(中英文),2023,40(06):733-740. DOI： 10.13568/j.cnki.651094.651316.2023.05.14.0002.

DOI：10.13568/j.cnki.651094.651316.2023.05.14.0002.

摘要

考察共载姜黄素和甘草酸的介孔硅敷料在蓝光照射下用于烫伤创面修复的潜力及初步作用机制．基于吸水特性检测敷料吸收创面渗出液潜力，根据创面愈合率、体重变化和病理切片检测评价敷料促进创面愈合能力，通过检测创面处血管内皮生长因子VEGF(Vascular Endothelial Growth Factor)的变化评价敷料促进血管生成功效、检测肝脏中的炎症因子白介素IL-1β(Interleukin-1β)评价对肝脏修护作用，利用在体抗菌活性检测敷料抗菌效果并通过对活性氧（ROS）的检测分析其抗菌机制．结果表明：载药后的微米介孔硅不影响本身的吸水特性．蓝光照射下对创面愈合率、病理特征、创面处抑制金黄色葡萄球菌能力、创面处VEGF和肝脏中IL-1β均同模型组有显著差异（P <0.05），其中抑菌能力可能来源于活性氧的产生．蓝光照射能缓解载药敷料对烫伤小鼠体重的降低（P <0.05）．蓝光能协同共载姜黄素和甘草酸的介孔硅敷料用于小鼠烫伤创面的恢复．

Abstract

To investigate the possibility and preliminary mechanism of μm-sized mesoporous silica(μm S) codelivering with curcumin(Cur) and glycyrrhizic acid(GA) as a wound-dressing(Cur+GA@μm S) for scald wound repair under blue light irradiation. The ability of the wound-dressing to absorb wound exudate was detected by water absorption characteristics. The ability of the wound-dressing to promote wound healing was evaluated by wound healing rate

body weight change and pathological section detection. The effect of the wound-dressing on angiogenesis was evaluated by detecting the change of Vascular Endothelial Growth Factor(VEGF) at the wound.The repair effect on the liver was evaluated by detecting the inflammatory factor Interleukin-1β(IL-1β) in the liver.The antibacterial effect of the wound-dressing was detected by in vivo antibacterial activity and was explaned by reactive oxygen species(ROS) production. The results showed that drug loading does not affect the water absorbancy of μm S. Under blue light irradiation

the wound healing rate

pathological characteristics

ability to inhibit staphylococcus aureus at the wound

VEGF at the wound and IL-1β in the liver caused by Cur+GA@μm S were significantly different from those in the model group(P <0.05). ROS production may be the reason of the inhibiton to staphylococcus aureus of Cur+GA@μm S. Cur+GA@μm S combined with blue light irradiation could alleviate the weight loss of scalded mice caused by the former(P <0.05). Cur+GA@μm S in photodynamic therapy with blue light can be used for the recovery of scald wounds in mice.

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