胚胎与输卵管互作研究前沿

马梅香; 刘子涵; 樊小龙; 于淑雅; 布阿依先·吾加合买提; 安礼友

doi:10.13568/j.cnki.651094.651316.2022.12.14.0002

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胚胎与输卵管互作研究前沿

工程技术 | 更新时间：2026-01-21

- 胚胎与输卵管互作研究前沿
- 胚胎与输卵管互作研究前沿
- 新疆大学学报（自然科学版中英文） 2023年40卷第4期页码：476-485
- 作者机构：
  
  新疆大学生命科学与技术学院新疆生物资源基因工程重点实验室
- 作者简介：
- 基金信息：
  
  新疆维吾尔自治区自然科学基金杰出青年科学基金“受精卵与输卵管互作对发育结局的影响”（2022D01E09）;大学生创新训练计划“受精卵与输卵管互作的初步研究”（202110755084）
- DOI：10.13568/j.cnki.651094.651316.2022.12.14.0002
  中图分类号： Q492
- 纸质出版：2023
- 稿件说明：
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[1]马梅香,刘子涵,樊小龙,等.胚胎与输卵管互作研究前沿[J].新疆大学学报(自然科学版)(中英文),2023,40(04):476-485.
[1]马梅香,刘子涵,樊小龙,等.胚胎与输卵管互作研究前沿[J].新疆大学学报(自然科学版)(中英文),2023,40(04):476-485. DOI： 10.13568/j.cnki.651094.651316.2022.12.14.0002.

DOI：10.13568/j.cnki.651094.651316.2022.12.14.0002.

摘要

哺乳动物自然繁殖过程中，在输卵管内精子与卵母细胞结合形成受精卵，随后在输卵管中缓慢移动并进行卵裂发育，这一阶段在不同物种中需要大致相当长的时间（3～4天），随后胚胎才会进入子宫完成着床，进入妊娠后发育．输卵管为受精和胚胎早期发育提供了合适的场所，同时也是初始态生命体初次接触的环境，胚胎与输卵管完成初次对话（互作），互作对胚胎的发育产生积极的影响，也对输卵管的生理状态产生了适应性调节．体外受精等辅助生殖技术的出现，使胚胎可以在体外产生和发育，但完全缺少了与输卵管互作的机会，造成了胚胎在形态、耐低温性、发育能力、妊娠率和表观遗传特征等方面比体内产生的胚胎差．然而，输卵管的作用一直被低估，胚胎与输卵管互作未被充分研究．通过解读输卵管与胚胎互作相关的研究进展，系统阐释互作的细胞与分子基础、已开展的互作研究、已有的互作研究方法．帮助读者更好地认识胚胎是如何完整准确完成早期发育的，提示在辅助生殖实践中需要关注胚胎与输卵管的互作事件．

Abstract

During natural reproduction in mammals

sperm combine with oocytes in the fallopian tube to form a zygote

which then slowly moves through the fallopian tube and undergoes cleavage development. This stage takes roughly a long time(3～4 days) in different species before the embryo enters the uterus to complete implantation and enter post-pregnancy development. The fallopian tube provides a suitable place for fertilization and early embryo development

and it is also the environment for the first contact of the initial living organisms. The embryo and fallopian tube complete the initial dialogue(interaction)

which has a positive impact on the development of the embryo

and also has an adaptive regulation on the physiological state of the fallopian tube. With the advent of assisted reproductive technology such as in vitro fertilization

embryos can be generated and developed in vitro

but they completely lack the opportunity to interact with the fallopian tube

resulting in embryos that are worse than those produced in vivo in terms of morphology

low temperature tolerance

development ability

pregnancy rate

and epigenetic characteristics. However

the role of the oviduct has been underestimated and the interaction between embryo and oviduct has not been fully studied. In this review

we summarize the research progress on the interaction between fallopian tube and embryo

and systematically explain the cellular and molecular basis of the interaction

the carried out interaction research

and the existing interaction research methods. This article will help readers better understand how embryos complete early development completely and accurately

and suggest the events of embryo-fallopian tube interaction that need to be paid attention to assisted reproductive practice.

关键词

Keywords

references

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