含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成

郭中献; 曹玲华

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含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成

更新时间：2026-01-21

- 含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成
- Journal of Xinjiang University (Natural Science Edition in Chinese and English) Vol. 110, Issue 2, Pages: 131-136(2008)
- 作者机构：
  
  新疆大学化学化工学院,新疆大学化学化工学院新疆乌鲁木齐830046,新疆,乌鲁木齐,830046
- 作者简介：
- 基金信息：
- DOI：
  CLC： O626.2
- Published：2008
- 稿件说明：
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[1]郭中献,曹玲华.含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成[J].新疆大学学报(自然科学版),2008,No.110(02):131-136+124.

郭中献, 曹玲华. 含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成[J]. Journal of Xinjiang University (Natural Science Edition in Chinese and English), 2008, 110(2): 131-136.
[1]郭中献,曹玲华.含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成[J].新疆大学学报(自然科学版),2008,No.110(02):131-136+124. DOI：

郭中献, 曹玲华. 含芳基四唑的糖氨基噁二唑/噻二唑衍生物的合成[J]. Journal of Xinjiang University (Natural Science Edition in Chinese and English), 2008, 110(2): 131-136. DOI：

摘要

以S-(1-芳基-1H-四唑-5-基)巯乙酰肼(1a～1c)和糖基异硫氰酸酯(2a

2b)为原料

高产率地合成了新的N-糖基-2-[S-(1-芳基-1H-四唑-5-基)巯乙酰氨基]硫脲3a～3f

然后分别在醋酸汞/乙醇体系或乙酸酐/磷酸体系中合环

得到一系列新的2-(1-芳基-1H-四唑-5-硫亚甲基)-5-糖氨基噁二唑/噻二唑化合物4a～4f

5a～5f.目标化合物的结构均经IR

1HNMR及元素分析确证.

Abstract

A series of new N-glycosyl-2-[S-(1-aryl-1H-tetrazol-5-yl)mercaptoacetamido]thioureas 3a～3f have been synthesized in high yields from S-(1-aryl-1H-tetrazol-5-yl)mercaptoacetohydrazine(1a～1c) and glycosyl isothiocyanates(2a

2b)

then 3a～3f were converted to a series of new 2-(1-aryl-1H-tetrazol-5-ylthiomethylene)-5-glycosylamino-oxadiazoles/thiadiazoles 4a～4f

and 5a～5f respectively under mercuric acetate/alcohol system or acetic anhydride/phosphoric acid system.All the target compounds were characterized by IR

1H NMR and elemental analysis.

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references

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