we study a discrete coupling within-host and between-host model in environmentally-driven infectious disease by the Non-standard finite difference method.We analyze the decoupling models which are divided into fast system and slow system.In the fast system
The basic properties on the positivity and boundedness of solutions and the existence of the infection-free
infected equilibria are established.By using the linearization methods
the local stability of infection-free equilibria and infected equilibria are established.In the slow system
we also prove the existence of endemic equilibrium and the local stability of the equilibria.
关键词
Keywords
references
Li M Y,Shu H.Global dynamics of an in-host viral model with intracellular delay[J].Bull Math Biol,2010,72:1492-1505.
Shi P,Dong L.Dynamical behaviors of discrete HIV-1 virus model with bilinear infective rate[J].Math Meth Appl,2014,37:2271-2280.
Hattaf K,Yousfi N,Tridane A.Mathematical analysis of a virus dynamics model with general incidence rate and cure rate[J].Nonlinear Anal:RWA.2012,13:1866-1872.
Feng Z,Velasco-Hernandez J,Tapia-Santos B.A mathemical model for coupling within-host and between-host dynamics in an environmentallydriven infectious disease[J].Mathemical Biosciences,2013,241:49-55.
Mickens R E.Nonstandard finite difference models of differential equations[M].Singapore:World Scientific,1994.
Mickens R E.Discretizations of nonlinear differential equations using explicit nonstandard methods[J].Journal of Computational and Applied Mathematics,1999,110:181-185.
Zhou Y,Cao H,Xiao Y.The Difference Equation and application[M].Binjing:Science Press,2014.(in Chinese)