共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面

金楠; 陈欣; 黄李琼

doi:10.13568/j.cnki.651094.651316.2023.05.14.0002

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共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面

更新时间：2026-01-21

- 共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面
- Journal of Xinjiang University (Natural Science Edition in Chinese and English) Vol. 40, Issue 6, Pages: 733-740(2023)
- 作者机构：
  
  1. 莆田学院药学与医学技术学院药学系
  2. 莆田学院药物分析与检验医学福建省高校重点实验室
- 作者简介：
- 基金信息：
- DOI：10.13568/j.cnki.651094.651316.2023.05.14.0002
  CLC： R285.5
- Published：2023
- 稿件说明：
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[1]金楠,陈欣,黄李琼.共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面[J].新疆大学学报(自然科学版)(中英文),2023,40(06):733-740.
[1]金楠,陈欣,黄李琼.共载姜黄素和甘草酸的微米介孔硅敷料协同蓝光修复小鼠烫伤创面[J].新疆大学学报(自然科学版)(中英文),2023,40(06):733-740. DOI： 10.13568/j.cnki.651094.651316.2023.05.14.0002.

DOI：10.13568/j.cnki.651094.651316.2023.05.14.0002.

摘要

考察共载姜黄素和甘草酸的介孔硅敷料在蓝光照射下用于烫伤创面修复的潜力及初步作用机制．基于吸水特性检测敷料吸收创面渗出液潜力，根据创面愈合率、体重变化和病理切片检测评价敷料促进创面愈合能力，通过检测创面处血管内皮生长因子VEGF(Vascular Endothelial Growth Factor)的变化评价敷料促进血管生成功效、检测肝脏中的炎症因子白介素IL-1β(Interleukin-1β)评价对肝脏修护作用，利用在体抗菌活性检测敷料抗菌效果并通过对活性氧（ROS）的检测分析其抗菌机制．结果表明：载药后的微米介孔硅不影响本身的吸水特性．蓝光照射下对创面愈合率、病理特征、创面处抑制金黄色葡萄球菌能力、创面处VEGF和肝脏中IL-1β均同模型组有显著差异（P <0.05），其中抑菌能力可能来源于活性氧的产生．蓝光照射能缓解载药敷料对烫伤小鼠体重的降低（P <0.05）．蓝光能协同共载姜黄素和甘草酸的介孔硅敷料用于小鼠烫伤创面的恢复．

Abstract

To investigate the possibility and preliminary mechanism of μm-sized mesoporous silica(μm S) codelivering with curcumin(Cur) and glycyrrhizic acid(GA) as a wound-dressing(Cur+GA@μm S) for scald wound repair under blue light irradiation. The ability of the wound-dressing to absorb wound exudate was detected by water absorption characteristics. The ability of the wound-dressing to promote wound healing was evaluated by wound healing rate

body weight change and pathological section detection. The effect of the wound-dressing on angiogenesis was evaluated by detecting the change of Vascular Endothelial Growth Factor(VEGF) at the wound.The repair effect on the liver was evaluated by detecting the inflammatory factor Interleukin-1β(IL-1β) in the liver.The antibacterial effect of the wound-dressing was detected by in vivo antibacterial activity and was explaned by reactive oxygen species(ROS) production. The results showed that drug loading does not affect the water absorbancy of μm S. Under blue light irradiation

the wound healing rate

pathological characteristics

ability to inhibit staphylococcus aureus at the wound

VEGF at the wound and IL-1β in the liver caused by Cur+GA@μm S were significantly different from those in the model group(P <0.05). ROS production may be the reason of the inhibiton to staphylococcus aureus of Cur+GA@μm S. Cur+GA@μm S combined with blue light irradiation could alleviate the weight loss of scalded mice caused by the former(P <0.05). Cur+GA@μm S in photodynamic therapy with blue light can be used for the recovery of scald wounds in mice.

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references

袁扬.用于烫伤修复的自愈合水凝胶的制备及其应用基础研究[D].西安:西北大学, 2021.

许行.地龙木耳散对大鼠深Ⅱ度烫伤创面修复作用的初步研究[D].青岛:青岛大学, 2022.

孙冰雪,李晓慧,崔佳润,等.烫伤模型的制备及对烫伤药膏治愈和镇痛药效的验证[J].长春中医药大学学报, 2022, 38(1):58-62.

林卉,庞荣清.间充质干细胞治疗严重烫伤诱导的肝脏损伤研究进展[J].实用医学杂志, 2022, 38(20):2630-2634.

李明鸣,武海龙,赵哲媛,等.磺胺嘧啶锌软膏联合依诺沙星软膏对烫伤感染小鼠菌落数及愈合的影响[J].解剖学杂志, 2021,44(1):26-30.

李娜.用于烧烫伤感染创面修复的双交联抑菌水凝胶的制备及性能研究[D].西安:西北大学, 2022.

张荣榕,赵彧,马翠霞,等.采用Box-Behnken响应面法优化金鉴灵软膏的制备工艺及其初步药效研究[J].中国新药杂志, 2019,28(19):2411-2419.

周虹,严伟恒,代强,等.负载姜黄素的羧甲基壳聚糖水凝胶对大鼠烫伤创面的修复作用研究[J].解剖科学进展, 2021, 27(6):697-700.

李敏.水溶性羧甲基壳聚糖-姜黄素纳米材料联合PACT对S. aureus和MDR S. aureus杀菌效果及机制探究[D].西安:陕西师范大学, 2019.

沈颖昕.源于经典名方玉红膏的有效物质及治疗烫伤作用的研究[D].长春:长春中医药大学, 2022.

金楠,阮志鹏,陈健敏.一种载药微米介孔硅、其透皮制剂及制备方法和应用:201911080998.X[P]. 2021-11-05.

余越,陶春,杨海跃.介孔二氧化硅纳米粒的制备及其作为不同功能的药物载体研究进展[J].中国新药杂志, 2017, 26(16):1906-1912.

JIN N, PYO S M, KECK C M, et al. Maximum loaded amorphous azithromycin produced using the wetness impregnation method with fractional steps for dermal prophylaxis against Lyme disease[J]. Pharmazie, 2019, 74:345-349.

JIN N, HE J, WU C, et al. Glycyrrhizic acid assists anti-psoriatic efficacy of a self-deformable curcumin loaded transdermal gel[J].Pharmaceutical Development and Technology, 2022, 27(3):282-289.

JIN N, LIN J, YANG C, et al. Enhanced penetration and anti-psoriatic efficacy of curcumin by improved smart Pearls technology with the addition of glycyrrhizic acid[J]. International Journal of Pharmaceutics, 2020, 578:119101.

何燕敏,施林林,刘振强,等.美皮康银离子敷料联合愈邦抗菌医用敷料治疗深Ⅱ度烫伤创面疗效观察[J].中国美容医学, 2022,31(12):36-39.

GUO J T, WANG T Y, YAN Z F, et al. Preparation and evaluation of dual drug-loaded nanofiber membranes based on coaxial electrostatic spinning technology[J]. International Journal of Pharmaceutics, 2022, 629:122410.

ELDER D E.利弗皮肤组织病理学:第1版[M].北京:科学出版社, 2019.

张同威,郑文杰,刘岩,等.原花青素对烫伤大鼠创面愈合及VEGF/VEGFR表达的影响[J].广西医科大学学报, 2022, 39(1):74-80.

TIAGO E, SARAH W, MARTIN V. The detection sensitivity of commonly used singlet oxygen probes in aqueous environments[J].Journal Photoc Photob B:Biology, 2020, 204:111787.

郝永伟.基于锰纳米材料的肿瘤微环境响应式治疗成像系统基础研究[D].郑州:郑州大学, 2018.

SUN A, QIAN D, WANG Z, et al. Protective effect of lipoic acid modification on brain dysfunctions of mice induced by mesoporous silica nanoparticles[J]. Chemical Engineering Journal, 2021, 415:128957.

罗喻超,刘辰鹏,黄明浩,等.裸花紫珠治疗烧烫伤模型大鼠活性部位的筛选及其作用机制研究[J].天然产物研究与开发, 2019,31(4):711-716.

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