冠心病患者载脂蛋白A1、载脂蛋白B与血小板平均分布宽度水平变化及其相关性分析

范平; 阿丽米拉·赛依提江; 高颖

doi:10.13568/j.cnki.651094.651316.2022.05.29.0001

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冠心病患者载脂蛋白A1、载脂蛋白B与血小板平均分布宽度水平变化及其相关性分析

更新时间：2026-01-21

- 冠心病患者载脂蛋白A1、载脂蛋白B与血小板平均分布宽度水平变化及其相关性分析
- Journal of Xinjiang University (Natural Science Edition in Chinese and English) Vol. 39, Issue 4, Pages: 470-475(2022)
- 作者机构：
  
  1. 新疆医科大学第一附属医院心脏中心心功能科省部共建中亚高发病成因与防治国家重点实验室
  2. 新疆医科大学第一附属医院综合内三科
- 作者简介：
- 基金信息：
- DOI：10.13568/j.cnki.651094.651316.2022.05.29.0001
  CLC： R541.4
- Published：2022
- 稿件说明：
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[1]范平,阿丽米拉·赛依提江,高颖.冠心病患者载脂蛋白A1、载脂蛋白B与血小板平均分布宽度水平变化及其相关性分析[J].新疆大学学报(自然科学版)(中英文),2022,39(04):470-475.
[1]范平,阿丽米拉·赛依提江,高颖.冠心病患者载脂蛋白A1、载脂蛋白B与血小板平均分布宽度水平变化及其相关性分析[J].新疆大学学报(自然科学版)(中英文),2022,39(04):470-475. DOI： 10.13568/j.cnki.651094.651316.2022.05.29.0001.

DOI：10.13568/j.cnki.651094.651316.2022.05.29.0001.

摘要

针对新疆医科大学第一附属医院符合纳入条件的151例冠心病住院患者采取回顾性和总结性分析，探讨冠心病患者血小板参数与载脂蛋白A1、载脂蛋白B的关系．收集2020年1月至12月符合纳入标准的冠心病患者的临床数据，同时纳入同期健康体检的329例住院患者作为对照组．观察两组患者血小板参数、载脂蛋白之间的差异性，采用线性回归分析冠心病患者血小板参数与载脂蛋白的关系．经统计分析，发现载脂蛋白A1、载脂蛋白B、血小板平均分布宽度在冠心病组与对照组之间存在显著性差异（P <0.05）．冠心病组患者中载脂蛋白B与红细胞计数、血红蛋白、血小板计数、血小板平均体积、血小板平均分布宽度之间均存在相关性，其中载脂蛋白B与血小板平均分布宽度之间存在显著相关性．研究结果提示载脂蛋白B和血小板平均分布宽度异常可作为冠心病早期诊断和治疗的临床参考，临床应同时关注载脂蛋白B和血小板平均分布宽度的指标水平变化．

Abstract

To explore the relationship between platelet parameters

apolipoprotein A1 and apolipoprotein B in patients with coronary heart disease

151 inpatients with coronary heart disease in the First Affiliated Hospital of Xinjiang Medical University were retrospectively and summarily analyzed. The clinical data of patients with coronary heart disease who met the inclusion criteria from January to December of 2020 were collected. At the same time

329 hospitalized patients who were included in the physical examination in the same period were used as the control group. The relationship between platelet parameters and apolipoprotein in patients with coronary heart disease was analyzed by linear regression statistical analysis showed that there were significant differences in the apolipoprotein A1

apolipoprotein B and platelet mean distribution width(PDW) between the coronary heart disease group and the control group(P <0.05). Inpatients with coronary heart disease

there were correlations between apolipoprotein B and erythrocyte count

hemoglobin

platelet count

mean platelet volume and PDW

among which there was a significant correlation between apolipoprotein B and PDW. The results suggest that the abnormal of apolipoprotein B and PDW can provide certainly clinical value for the early diagnosis and treatment of coronary heart disease. Clinical attention should be paid to the changes of the levels of apolipoprotein B and PDW at the same time.

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references

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